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"In patients with urinary tract infections, institution of specific therapy should be preceded by careful examination of the urine and quantitative bacteriology from properly collected urine specimens. A clinical study on patients with urinary tract infections was done for observation of the changing trend in causative organisms and their susceptibility to antibiotics at Yonsei Medical Center in 1971 and 1976. The following results were obtained. 1) In 1971, 571 patients (male:2l1, female :360) with urinary tract infections were observed and in 1976, 647 patients (male :265, female :382) were observed. The ratio of male to female was 1 : 1.4-1.7, the most cases (above 60%) belonged to age group 20-49 years in both year. 2) The causative organisms of urinary tract infections were E. coli, enterobacter, staphylococcus and etc in 1971 and E. coli, enterobacter, klebsiella and etc in 1976 orderly. Cases of urinary tract infections by enterobacter and staphylococcus were decreased and cases by klebsiella, proteus and pseudomonas were increased in 1976. Urinary tract infections by E, coli were about 60% of female patients and about 25% of male patients in both year. Incidence of mixed urinary tract infections was l0.5% in l971 and 15.1% in 1976. 3) The susceptibility rates of gram negative organisms were 30.3% to ampicillin, 72.2% to Kanamycin, 79.9% to neomycin and 51,5% to bactrim in l971 and 17.5% to ampicillin, 47.8% to Kanamycin, 68.7% to gentamycin and 71.8% to colimycin in 1976. The rates to chloramphenicol, streptomycin and tetracycline were about 20% in both year. 4) The susceptibility rates of gram positive organisms were 35.4% to chloramphenicol, 38.5% to orbenin, 81.0% to penicillin G and 11.8% to tetraycline in 1971 and 50.0% to chloramphenicol, 31.6% to orbenin, 64.5% to penicillin G and 22.4% to tetracycline in 1976. The rate to ampicillin in 1971 was 57.0% and to cephaloridin in 1976 was 78.9%. 5) The susceptibility rates of Pseudomonas were 79.5% to colimycin and 59.1% to neomycin in 1971 and 88.7% to colimycin, 56.3% to gentamycin and 59.2% to carbenicillin in 1976. The rates to streptomycin, tetracycline, bactrim and minocycline were low."
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